IndraLab

Statements

Amodiaquine inhibits heme. 5 / 5
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"This is evidenced by the ABS-active, liver stage-inactive 4-aminoquinolines chloroquine, amodiaquine and piperaquine that inhibit hemoglobin degradation and heme detoxification, and artemisinin derivatives whose activation inside parasites requires heme-iron that is a product of hemoglobin degradation 5."
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"Indeed atomic-force microscopy studies have shown that the various antimalarial 4-aminoquinolines affect the biomineralization of heme molecules in different ways, with CQ and quinine providing the most efficient blocking by forming interactions across the flat surface face (“step-pinning”), whereas MFQ and amodiaquine block addition of heme only to the step edge (“kink-blocking”)."
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"It is well established that CQ and amodiaquine (AQ) accumulate in the parasite 's food vacuole and inhibit heme polymerization, thereby increasing its efflux out of the food vacuole."
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"However, earlier reports have shown that amodiaquine inhibits the polymerization of heme to the insoluble product, hemozoin, in the parasite (Ginsburg et al. 1998)."
32638101
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"Several 4-aminoquinolines, notably chloroquine (CQ) and amodiaquine (AQ), are thought to act primarily by binding hemozoin crystals at their actively growing surfaces and thus preventing further incorporation and detoxification of free heme."
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