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Hydroxychloroquine activates IgG. 4 / 4
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"Patients with PAPS with medium-to-high anti-beta2GPI antibody titers of either IgG or IgM isotype had higher IFN scores, whereas those treated with hydroxychloroquine had lower scores, after adjusting for age and gender and other APS related factors."
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"These cells present another potential target for HCQ since HCQ effectively suppresses the class-switch of memory B cells to plasma cells and also decreases the production of IgG (Torigoe et al., 2018; Kowatsch et al., 2023), both of which are increased in PE (Liao et al., 2009)."
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"Moreover, hydroxychloroquine has been reported to increase salivary flow rate by inhibiting glandular cholinesterase [XREF_BIBR], decrease inflammatory indices, that is, ESR and C reactive protein (CRP), and immunological abnormalities, that is, gamma-globulin, IgG, IgM, RF, anti-Ro, anti-La."
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"It has been shown that HCQ inhibits differentiation of class-switched memory B cells into plasmablasts and thereby decreases IgG production in response to TLR9 stimulation or inoculation with inactivated virus [14, 15]."
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