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"In conclusion , the present study demonstrated that LPS could inhibit the expression of ACE2 by upregulating the levels of miR-200c-3p and by suppressing the NF-kappaB pathway ."
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"LPS injection significantly elevated renal ACE activity (Figure 9A), urinary renin activity (Figure 9B), urinary prorenin/renin excretion (Figure 9C), and urinary Ang II excretion (Figure 9D), but decreased renal ACE2 activity (Figure 9E) and urinary Ang1-7 excretion (Figure 9F), which were significantly abolished by Tiliroside administration."
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"Lipopolysaccharide ( LPS ) stimulates acute lung injury via inducing ACE and AT1R expression , and inhibiting ACE2 expression , which can be rescued by vitamin D treatment ( Xu et al ., 2017 ) ."
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"LPS can induce the decrease of ACE2 and the increase of AngII [27] ."
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"XREF_BIBR In a rat acute respiratory distress syndrome (ARDS) model, a combination of lipopolysaccharide and mechanical ventilation decreased the ACE2 and ACE activity and Ang-(1-7)/Ang II concentration ratios in bronchoalveolar lavage fluid."
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"ACE2 overexpression reversed LPS induced ACE2 decrease and enhanced Mas mRNA increase in lung."
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"The combination of the results in vivo and in vitro suggests the direct hepatoprotection of GA.It has been reported that LPS decreased renal ACE2 signaling, accompanied by activation of renal Ang II a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Losartan also inhibited the LPS mediated decrease in angiotensin converting enzyme 2 activity and the labeling of this enzyme in the lung."
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"Furthermore, we found that ML365 administration increased ACE2 content suppressed by LPS ( Fig. 4 E)."
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"microRNA-1246 mediates lipopolysaccharide induced pulmonary endothelial cell apoptosis and acute lung injury by targeting angiotensin converting enzyme 2."
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"LOS also inhibited the LPS mediated decrease in angiotensin converting enzyme 2 (ACE2) activity (p < 0.05)."
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"In addition , compared with the control group , LPS significantly reduced the expression levels of ACE2 ( Fig. 2C ) , while IL-1beta and IL-6 mRNA expression levels significantly increased ( Fig. 2D and E ) ."
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"The lipopolysaccharides (LPS)-induced bronchoalveolar lavage fluid increased the ACE2 activity but administration of cAng-II (1–7), significantly reduced the ACE2 activity in animals."
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"Previously, we demonstrated that administration of bacterial LPS into mouse lung attenuated pulmonary ACE2 activity dynamically."
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"We found that LPS induced the decrease in ACE2 protein in lung tissue and promoted its ubiquitination, indicating that LPS treatment can reduce the activity of ACE2 protein through its ubiquitination,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although no studies suggest that LPS directly down-regulates ACE2 expression , there are data that Ang II can decrease ACE2 mRNA by 60 % in certain cell types , such as astrocytes ( 33 ) ."
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