IndraLab

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"Losartan also inhibited the LPS mediated decrease in angiotensin converting enzyme 2 activity and the labeling of this enzyme in the lung."
20107763
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"Lipopolysaccharide ( LPS ) stimulates acute lung injury via inducing ACE and AT1R expression , and inhibiting ACE2 expression , which can be rescued by vitamin D treatment ( Xu et al ., 2017 ) ."
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"In conclusion , although LPS can inhibit the expression of ACE2 by upregulating the levels of miR-200c-3p through the NF-kappaB pathway , APC inhibited this effect , thus reducing inflammation during LPS-induced ALI ."
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"Previously, we demonstrated that administration of bacterial LPS into mouse lung attenuated pulmonary ACE2 activity dynamically."
31645418
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"microRNA-1246 mediates lipopolysaccharide induced pulmonary endothelial cell apoptosis and acute lung injury by targeting angiotensin converting enzyme 2."
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"ACE2 overexpression reversed LPS induced ACE2 decrease and enhanced Mas mRNA increase in lung."
27302421
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"SARS binding , lipopolysaccharide , sepsis and acid treatment all result in ACE2 downregulation in lung ."
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"34 In a rat acute respiratory distress syndrome (ARDS) model, a combination of lipopolysaccharide and mechanical ventilation decreased the ACE2/ACE activity and Ang-(1-7)/Ang II concentration ratios in bronchoalveolar lavage fluid."
| PMC
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"In conclusion , the present study demonstrated that LPS could inhibit the expression of ACE2 by upregulating the levels of miR-200c-3p and by suppressing the NF-kappaB pathway ."
33747178
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"In addition , compared with the control group , LPS significantly reduced the expression levels of ACE2 ( Fig. 2C ) , while IL-1beta and IL-6 mRNA expression levels significantly increased ( Fig. 2D and E ) ."
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"These results suggest that the anti-inflammatory response may be also triggered in lung by LPS exposure to counter the effects of pro-inflammatory cytokines, and ACE2 promotes anti-inflammatory response via Ang-(1-7)/Mas pathway.ACE2 overexpression reversed LPS-induced ACE2 decrease and enhanced Mas mRNA increase in lung."
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"LOS also inhibited the LPS mediated decrease in angiotensin converting enzyme 2 (ACE2) activity (p < 0.05)."
19529910
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"Lipopolysaccharide ( LPS ) stimulates acute lung injury via inducing ACE and AT1R expression , and inhibiting ACE2 expression , which can be rescued by vitamin D treatment ( Xu , Yang , Chen et al ., 2017 ) ."
33781838
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"Although no studies suggest that LPS directly down-regulates ACE2 expression , there are data that Ang II can decrease ACE2 mRNA by 60 % in certain cell types , such as astrocytes ( 33 ) ."
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"The lipopolysaccharides (LPS)-induced bronchoalveolar lavage fluid increased the ACE2 activity but administration of cAng-II (1–7), significantly reduced the ACE2 activity in animals."
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"The present results demonstrated that LPS significantly downregulated the expression of ACE2 , while APC significantly reduced LPS-induced ALI and provided beneficial effects ."
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"XREF_BIBR In a rat acute respiratory distress syndrome (ARDS) model, a combination of lipopolysaccharide and mechanical ventilation decreased the ACE2 and ACE activity and Ang-(1-7)/Ang II concentration ratios in bronchoalveolar lavage fluid."
| PMC