IndraLab

Statements


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"In a culture system mimicking pSS pathology by TCR/TLR9 stimulation of PBMCs of pSS patients, a combination of LEF and HCQ complementarily inhibited T and B-cell proliferation, production of IFN-α, CX[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"production remains unchainged (c) : IgG and IgM are strongly inhibited by HCQ and LEF in HC and pSS patients."

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"Furthermore, IgG effects are blocked by a specific FXa inhibitor as well as HCQ and fluvastatin."

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"XREF_BIBR Hydroxychloroquine, an effective and widely used therapy in SLE patients inhibits the DNA sensing TLR9 pathway and was demonstrated to inhibit IgG secretion by B cells stimulated with NET derived LL37-DNA complexes."

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"Both pooled and subgroup analyses showed that the combination of TGP and HCQ reduced IgG in patients more than HCQ alone."