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"58 As shown in XREF_FIG, Cd impaired the maturation of CTSB and CTSD in rPT cells, which was markedly restored by cotreatment with Tre."

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"Consistently, Cd exposure impaired the maturation of CTSB and CTSD in rPT cells, which was significantly restored by the addition of Tre."

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"Immunoblot analysis confirmed that Cd-disrupted maturity of CTSB and CTSD were effectively rescued by inhibition of prolonged Nrf2 activation in vitro and in vivo ( Fig. 4 D)."