IndraLab

Statements

reach
"The suggested beneficial effect of IL-1 blocking (anakinra) and autophagy inhibition (HCQ) in IRP supports its autoinflammatory nature, although the precise pathogenic mechanisms remain to be elucidat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32312616
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"Chloroquine and hydroxychloroquine were able to elevate IL-1β-induced cytokine production in macrophages, which is in line with previous studies in cutaneous dendritic cells [12] ."
32088265
reach
"On the other hand, the immune-modulating effect of HCQ is represented in inhibition of signaling of the toll-like receptor and reducing the production of IL-1 and IL-6 [5]."
| PMC
reach
"Previous studies having shown that chloroquine and hydroxychloroquine could reduce interleukin 1 (IL-1)-induced cartilage degradation in-vitro, the effects of a range of antimalarial drugs on the cartilage proteoglycan degrading actions of porcine leucocyte (pI 4.8) alpha-interleukin 1 (syn."
2879013