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Hydroxychloroquine activates BC001. 16 / 16
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"These finding indicates HCQ promotes the anticancer effect of BC001 in BGC823 cells partially via regulating immune responses."
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"Hydroxychloroquine enhances the antitumor effects of BC001 in gastric cancer."
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"In the present study, hydroxychloroquine (HCQ), an inhibitor of autophagy, enhanced the antiproliferative and proapoptotic effects of BC001 in vitro."
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"In this study, our results suggested that HCQ inhibited the growth of BGC823 cells, and promoted the antiproliferative properties of BC001."
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"Furthermore, HCQ enhanced the antitumor effects of BC001 on BGC823 xenograft tumors in vivo."
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"In summary, HCQ was proposed to enhance the anticancer effects of BC001 in gastric cancer via complex mechanisms."
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"Although, whether HCQ promotes the anticancer effect of BC001 in gastric cancer and whether BC001 induces autophagy remain unclear.In the present study, we reported that HCQ enhanced the antiproliferative and proapoptotic properties of BC001 in vitro, and promoted the antitumor effects of BC001 on a BGC823 cell-based xenograft tumor in vivo."
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"Therefore, HCQ may enhance the anticancer activity of BC001 in gastric cancer."
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"Therefore, our findings suggested that HCQ may enhance the anticancer effects of BC001 in gastric cancer via complex mechanisms."
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"HCQ promotes the antitumor effects of BC001 in vitro."
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"In conclusion, our results suggested that HCQ increased anticancer activity of BC001 in gastric cancer, suggesting that the combined treatment of HCQ and BC001 may be considered as a promising approach for the treatment of gastric cancer."
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"Of note, HCQ significantly enhanced the anti-proliferative effect of BC001 (Fig. 1B)."
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"In addition, we investigated whether HCQ could promote BGC823 apoptosis together with BC001."
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"HCQ enhances the anticancer activity of BC001 in vivo."
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"This indicated that HCQ also increased the anticancer effects of BC001 in vivo by inhibiting cell growth and promoting apoptosis."
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"HCQ actives multiple pathways to promote the anticancer effects of BC001 in BGC823 cells."
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