IndraLab

Statements

Leupeptin inhibits ACE2. 3 / 3
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"HIV-luc(ACE2) and HIV(SARS-CoV S/ASLV-A env) particles were mixed, pre-incubated at 37 o C and then treated with PBS, trypsin (10 µg/ml), or cathepsin L or B (2 µg/ml) for 10 minutes at 25 o C. Proteases were inactivated by leupeptin (20 µg/ml), incubated at 37 o C for 30 minutes to allow membrane fusion and plated on HeLa/Tva cells pretreated with leupeptin (20 µg/ml)."
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"Interestingly, while the Ang-II pressor response was similar in NT and ACE2 -/y, leupeptin was not able to inhibit the Ang-II-induced hypertension in ACE2 -/y mice (XREF_FIG)."
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"ACE2 degradation in lysosomes could be blocked by leupeptin, inhibitor of lysosome and was dependent on the ubiquitination of ACE2 endodomain, triggered by high levels of Ang II (73)."
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