IndraLab

Statements



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"The possible pathogenesis of macular edema caused by hydroxychloroquine might be related to alteration of blood-retinal barrier, which resulted from RPE damage caused by hydroxychloroquine due to its toxicity and resulted in fluid accumulation."

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"RPE dysfunction caused by long-term use of hydroxychloroquine can be manifested as pigment epithelium detachment."

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"Thus, CQ and HCQ rapidly enhance RPE barrier permeability in vitro, independent of cytotoxicity or loss of zonula occludens-1, claudin-1, and occludin expression."