IndraLab

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"For the objective indexes, as salivary flow rate was only measured in one study which could not be used for meta-analysis, so only the pooled weighted mean difference of the ESR and Schirmer test were analyzed (Table 5), and it was found that HCQ treatment could reduce the ESR of SS patients (Z = −2.19, P < 0.05; Fig. 10), however, there was no statistically significant difference in Schirmer test (Z = 0.04, P = 0.97; Fig. 11)."
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"And HCQ treatment could also reduce the ESR of pSS patients,however, when considering the treatment result of Schirmer test, no significant difference between HCQ and control groups was found."
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"Salicylates, indomethacin, phenylbutazone and hydroxychloroquine produce some clinical improvement but do not lower the high ESR; moreover, the patients are prone to experience relapses."
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"These results were not completely consistent with previous related studies, which have shown that HCQ can improve patient 's fatigue and joint symptoms, and effectively reduce immunoglobulin, ESR, and CRP levels [XREF_BIBR, XREF_BIBR]."
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"The combining results of these three studies showed that when compared with placebo group, HCQ treatment could effectively reduce ESR in patients with pSS."
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"Therefore, it was concluded that HCQ had no effect upon pain, fatigue, but HCQ could reduce the ESR of pSS patients.With regard to the safety of HCQ in the treatment of SS, three [31, 37, 39] of the four studies recorded side effects or adverse events after treatment."
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"TGP + HCQ, TGP + TGT, IGU + TGP can be considered as an alternative to IGU + HCQ when reducing ESR and IgG."
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"It can be seen that the TGP is important in promoting glandular secretion.According to the meta‐analysis published by Wang et al., 3 HCQ could reduce ESR compared with PBO."
37904705
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"Our pooled data indicated that TGP + HCQ is superior to HCQ alone in reducing ESR."
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"Subgroup analysis suggested that Lu et al. 20 is a source of the statistical heterogeneity, which showed PDN + HCQ + TGP is superior to PDN + HCQ in reducing ESR."
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"Previous research studies have shown that HCQ or TGP can reduce ESR; thus, IGU might enhance the anti-inflammatory activity of HCQ or TGP through a synergistic effect or independent pathways."
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