IndraLab

Statements

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"In an attempt to reduce toxicity, hydroxychloroquine was synthesized by adding a hydroxyl group into one of the N-ethyl groups of chloroquine [1, 2]."
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"Beyond the optimal concentration of H O , the rate of hydroxychloroquine degradation reduced due to the radical reduction of OH [1], [35]."
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"By introducing a hydroxyl group into CQ, hydroxychloroquine (HCQ) was synthesized in 1946, and it was approved for medical use as an alternative to CQ because of its favorable efficacy and reduced tox[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Hydroxychloroquine (HCQ), a derivative of CQ ( Fig. 3 ), was first produced in 1946 by introducing a hydroxyl group into CQ and was shown to be much less toxic than CQ in animals [ 39 ]."
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"Hydroxychloroquine (HCQ) was synthesized in 1946 as an analog of chloroquine by adding a hydroxyl group at the carbon number 7, and it exhibits fewer side effects but the same efficacy [1]."
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"Among the previously proposed treatments for COVID-19, hydroxychloroquine has been shown to increase 25 (OH) D levels [21], while vitamin D replacement therapy has been suggested as a simpler and less expensive alternative to tocilizumab, an antiInterleukin-6 (IL-6) receptor monoclonal antibody [22]."
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"On the other hand, Ruiz-Irastroza and al. found higher 25 (OH) D concentration in SEL patients who were treated with hydroxychloroquine [XREF_BIBR]."
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