IndraLab

"Further, combination with lisinopril suppressed the upregulation of ACE2 mRNA by vildagliptin ( Figure 4A )."

"Captopril , enalapril , and lisinopril block ACE but not ACE2 and may be counterproductive ."

"Captopril, enalapril, and lisinopril block ACE but not ACE2 and may be counterproductive."

"ACE2 is not inhibited by the ACE inhibitors captopril, lisinopril and enalaprilat."

"Higher concentration of lisinopril will completely block ACE due to selective binding to ACE but at a higher dose of 160 μg/mL, lisinopril inhibits ACE2 only by 4%."

"One theory posits that binding of ACE-2 receptors by SARS coronaviruses in pulmonary vascular endothelium leads to downregulation of these receptors and abrogation of normal vasoregulation in these regions.42 Indeed, ACE-2 inhibition by lisinopril has previously been shown to attenuate hypoxic pulmonary vasoconstriction.43 Although this theory is intriguing, the renin-angiotensin-aldosterone system remains a minor contributor to pulmonary vasoregulation in comparison to the release of local mediators (endothelin, prostacyclin, and nitric oxide), which could be affected by direct viral injury to pulmonary artery endothelial cells."

"In these studies we found that the combination of lisinopril and losartan abrogated the upregulation of cardiac ACE2 mRNA that was observed when animals were administered the single treatments."

"ACE2 is not inhibited by lisinopril or captopril."

"ACE2 is not inhibited by lisinopril or captopril ."

"It has been shown that captopril, enalaprilat, lisinopril, cilazaprilat, indolaprilat, perindoprilat, quinaprilat and spiraprilat, rentiapril, zofenapril, ceranopril, and fosinoprilat fail to inhibit the peptidase activity of ACE2 at doses that affect ACE function [33,34]."