IndraLab

Statements

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"Then, mice brains were sampled and analyzed to quantify levels of GM1 ganglioside; AF488-CTB staining revealed that both amodiaquine and thiethylperazine treatments could reduce the signal of GM1 ganglioside in the BKO mice compared with the controls (XREF_FIG A and XREF_SUPPLEMENTARY A)."
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"These results suggest that both amodiaquine and thiethylperazine can reduce GM1 ganglioside accumulation and recover the presynaptic dysfunction characteristic of disease derived neurons."
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"Among them, amodiaquine and thiethylperazine also reduced GM1 ganglioside accumulation in the model mice."
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"We showed that amodiaquine and thiethylperazine reduced GM1 ganglioside accumulation with activating autophagy."
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