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Enalapril inhibits ACE2. 16 / 18
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"Enalapril treatment also reduced the myocardial ACE and ACE2 ratio, both at the mRNA and the protein level."
27633002
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"Enalapril attenuates downregulation of Angiotensin converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat."
| DOI
eidos
"Captopril , enalapril , and lisinopril block ACE but not ACE2 and may be counterproductive ."
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"Enalapril attenuates downregulation of angiotensin converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat."
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"RT-qPCR, western blot analysis and immunohistochemistry assays demonstrated that enalapril pre-treatment successfully suppressed the upregulation of ACE but not ACE2 upon CA and resuscitation."
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"The highest dose of 140 µg/mL enalapril inhibited ACE2 activity by 93%, while 92% inhibition was observed with the highest dose of 80 µg/mL of benazeprilat."
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"In an animal model, the ACEI enalapril attenuated the downregulation of cardiac ACE2 after myocardial infarction."
32607467
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"Enalapril attenuates downregulation of Angiotensin converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat."
16908757
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"Captopril, enalapril, and lisinopril block ACE but not ACE2 and may be counterproductive."
33747262
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"Ocaranza, M. P.; Godoy, I.; Jalil, J. E.; Varas, M.; Collantes, P.; Pinto, M.; Roman, M.; Ramirez, C.; Copaja, M.; DiazAraya, G.; Castro, P.; Lavandero, S., 2006 : Enalapril attenuates downregulation of Angiotensin converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat."
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"Similarly to how ACE2 receptor inhibitors reduced SARS-CoV-1-induced acute respiratory distress syndrome (ARDS) [17] , it seems that efforts to develop ACE2 receptor inhibitors (also known as ACE2 blo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34521025
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"Enalapril markedly reduced ACE and significantly elevated ACE2."
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"While enalapril dose-dependently decreased mean arterial pressure, the cardiac index and PaO /FiO ratio were higher in patients treated with enalapril than in the control group.After a successful phase I study of pharmacokinetics and pharmacodynamics of recombinant human (rh)ACE2 in healthy volunteers (Haschke et al., 2013), a clinical trial in patients with ARDS was terminated prematurely because the predefined effects on outcome were not achieved (Khan et al., 2017)."
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"Similarly to how ACE2 receptor inhibitors reduced SARS-CoV-1-induced acute respiratory distress syndrome (ARDS) [17], it seems that efforts to develop ACE2 receptor inhibitors (also known as ACE2 blockers such as enalapril, lisinopril, captopril, perindopril [18], [19]) for SARS-CoV-2 may be beneficial (Fig. 1 A)."
| PMC
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"Enalapril decreases the myocardial ACE and ACE2 mRNA ratio in a swine model of CA and resuscitation."
27633002
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"However , enalapril could attenuate downregulation of ACE2 in myocardial infarcted rats [ 74 ] and prevent cardiac hypertrophy and dysfunction ."
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