IndraLab

Statements

Enalapril inhibits ACE2. 12 / 12
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No evidence text available
2160536
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"Similarly to how ACE2 receptor inhibitors reduced SARS-CoV-1-induced acute respiratory distress syndrome (ARDS) [17], it seems that efforts to develop ACE2 receptor inhibitors (also known as ACE2 blockers such as enalapril, lisinopril, captopril, perindopril [18], [19]) for SARS-CoV-2 may be beneficial (Fig. 1 A)."
| PMC
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"In an animal model, the ACEI enalapril attenuated the downregulation of cardiac ACE2 after myocardial infarction."
32607467
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"Captopril, enalapril, and lisinopril block ACE but not ACE2 and may be counterproductive."
33747262
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No evidence text available
| DOI
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"However , enalapril could attenuate downregulation of ACE2 in myocardial infarcted rats [ 74 ] and prevent cardiac hypertrophy and dysfunction ."
33396184
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"RT-qPCR, western blot analysis and immunohistochemistry assays demonstrated that enalapril pre-treatment successfully suppressed the upregulation of ACE but not ACE2 upon CA and resuscitation."
27633002
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"Enalapril attenuates downregulation of Angiotensin converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat."
16908757
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"In an animal model, the ACEI enalapril attenuated the downregulation of cardiac ACE2 after myocardial infarction.6465There is a clear benefit of ACEI and ARB in reducing thrombotic effects in hypertensive patients.6667Protection against severe lung damage could also be achieved by administering recombinant ACE2."
32607467
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"Enalapril treatment also reduced the myocardial ACE and ACE2 ratio, both at the mRNA and the protein level."
27633002
eidos
"Captopril , enalapril , and lisinopril block ACE but not ACE2 and may be counterproductive ."
33747262
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"Enalapril decreases the myocardial ACE and ACE2 mRNA ratio in a swine model of CA and resuscitation."
27633002