IndraLab

Statements

Hydroxychloroquine inhibits Kr. 7 / 7
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"Hydroxychloroquine reduces a repolarizing current (I Kr), while AZM increases a depolarizing current (late I Na)."
34009333
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"XREF_BIBR As modelled in the present study, cardiomyocytes harbouring mutations leading to haplo-insufficiency in KCNQ1 may present very minimal action potential prolongation because of a normal I Kr, XREF_BIBR but I Kr blockers such as HCQ, can lead to marked action potential prolongation in limited repolarization reserve."
34009333
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"As modelled in this study, despite the absence of QT prolongation in baseline conditions because of a normal I Kr XREF_BIBR and regardless of the origin of low repolarization reserve, these patients are at high risk of TdP when I Kr blockers such as HCQ are used."
34009333
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"to antagonize fibrillation following action potential shortening and inhomogeneity during ischemia.In SA node cells, Purkinje fibers and ventricular myocytes, hydroxychloroquine was shown to decrease the amplitude of the rapid delayed rectifier I Kr by 35 % [61] ."
| DOI
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"By blocking -in order of increasing potency -the delayed (I Kr ) and inwardly-rectifying (I K1 ) K + currents [80] , and the latter preferentially at depolarised E m , CQ and HCQ significantly prolong the QT interval and slow ventricular conduction, thereby predisposing to early-after-depolarisation and, by extension, torsades de pointe."
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"Chloroquine and hydroxychloroquine inhibited I Kr (IC 50 : 1microM and 3-7microM, respectively) and I K1 currents (IC 50 : 5 and 44microM, respectively)."
33620150
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"XREF_BIBR In particular, the magnitude of the proarrhythmic potential of these drugs, specifically related to their QT prolongation effects, is questioned : On the one hand, the fact chloroquine and hydroxychloroquine block the I Kr potassium-channel at the myocyte level, therefore causing QT prolongation, is well documented."
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