IndraLab

"Computer based quantitative measurements of IgG localization showed that HCQ markedly reduced the binding of aPL IgG to the SCTs."

"Hydroxychloroquine (HCQ) has been shown to decrease aPL titers in laboratory studies."

"23 Hydroxychloroquine has also been found to reverse the effects of aPL on annexin A5 and coagulation on the surface of trophoblasts, and it prevents the effects of aPL on trophoblast migration, hCG secretion and fusion."

"Hydroxychloroquine decreased aPL titers and lowered the odds of having persistently positive aPL in an observational study."

"XREF_BIBR - XREF_BIBR The current results provide the first confocal microscopic imaging evidence that HCQ reverses the binding of aPL antibodies to human placental SCTs and that the drug restores AnxA5 expression."

"22 Observational studies in humans have also suggested a beneficial effect for the drug in reducing the risk of thrombosis XREF_BIBR - XREF_BIBR We showed, through ellipsometry and atomic force microscopic imaging of aPL immune complexes on planar phospholipid bilayers, that HCQ directly disrupts the formation of aPL immune complexes XREF_BIBR, XREF_BIBR and that this restores AnxA5 binding and crystallization on the planar bilayers, XREF_BIBR, XREF_BIBR Also, using quantitative immunoassays, we demonstrated that the drug also reduced aPL binding and restored AnxA5 expression on cultured BeWo trophoblasts."

"Rand and 239 colleagues 108, 109, demonstrated that HCQ reduces the binding of aPL autoantibodies and beta2GPI carriage 120."