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Hydroxychloroquine activates immune response. 17 / 17
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"However, chloroquine and hydroxychloroquine modulate the patient’s immune response and, for this reason, have the disadvantage of suppressing the immune response against the tumor when administered for long periods, because of their immunosuppressive activity [17]."
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"Based on the evidence that hydroxychloroquine and chloroquine inhibit lysosome turnover, and consequently the antigen presentation initiating the immune response,38 there has been a large empirical use of antimalarial drugs at the beginning of the pandemic with the purpose to damper the adverse events and the hospitalization duration."
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"Finally , HCQ promotes the immune response through enhancing antigen expression by the dendritic cells thus activating cytotoxic T-lymphocytes ."
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"Treatment of SLE in generalImmunomodulatorsHydroxychloroquine (HCQ): Hydroxychloroquine (HCQ) modulates the immune response pleiotropically by inhibiting B-cell receptor and Toll-like receptor (TLR) signaling, as well as intracellular TLR-3 and TLR-7 activation, which is important in nucleic acid sensing [25,26]."
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"Hydroxychloroquine leads to a drop in ROS production in immune cells, increasing immune response and leading to cell cycle arrest in tumour cells [175]."
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"Hydroxychloroquine prevented the induction of epigenetic modifications needed for trained immunity.81 Preoperative exercise therapy triggered an anti‐inflammatory trained immunity phenotype via metabolic reprogramming and led to attenuation of liver injury and inflammation from ischemia in mouse models.82 Sterile tissue injury trained the innate immune system, providing protection against subsequent infection in adult drosophila."
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"Hydroxychloroquine pleiotropically modulates the immune response by inhibition of B cell receptor and TLR signaling as well as intracellular TLR-3 and-7 activation, fundamental in nucleic acid sensing [XREF_BIBR - XREF_BIBR]."
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"Therefore, we used HCQ to treat Lewis-bearing nude mice (T cell-deficient) to explore the role of the T cell-induced anti-tumour immune response in NSCLC suppression."
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"Hydroxychloroquine is believed to increase the endosomal pH needed for virus-cell fusion , interfere with glycosylation of the ACE2 receptor , and modulate the immune response [ 12 ] ."
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"By adding dual RAS blocker, we would be treating COVID-19 with three different pathways : the antiviral reduces the viral load, HCQ blocks the entry of Sars Cov2 via ACE2 blockade and modulate immunity, and the ACEi plus ARBs plus tetanus-diphtheria vaccine inhibits and modulates the RAS dependent immune response."
| PMC
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"Collectively, these results demonstrated that HCQ enhanced the immune response induced by IR combined with PD-L1 deficiency by amplifying IFN-β signaling, thereby intensifying the growth of primary and distal tumors."
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"Thus, we hypothesized that HCQ may lead to the transformation of TAMs to induce anti-tumour T cell immunity in orthotopic lung cancer."
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"Moreover, the inhibitory effect of HCQ on TLR expression decreases the aberrant immune response typically found in rheumatic diseases."
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"It was concluded in two studies that only hydroxychloroquine can enhance influenza immunity among SLE patients."
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"We recently found that chloroquine, hydroxychloroquine and the β-adrenoreceptor blocker propranolol enhance pro-inflammatory immune response under sterile inflammatory conditions correlating with p38 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"By adding dual RAS blocker, we would be treating COVID-19 with three different pathways: the antiviral reduces the viral load, HCQ blocks the entry of Sars Cov2 via ACE2 blockade and modulate immunity[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CQ and HCQ might also be able to modulate the over activated immune response."
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