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Sulfate inhibits CTSB. 2 / 2
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"Utilising the ability of CpsB to dephosphorylate pNPP, we performed a screen of a marine extract library culminating in the discovery of a novel meroterpene sulphate, FQE, which inhibited CpsB phosphatase activity with an IC 50 of 5.21 microM."
22629313
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"The synthetic protease inhibitor bis [ethyl (2R,3 R)-3-[(S)-methyl-1-[4-(2,3,4-tri-methoxyphenyl-methyl) piperazine-1-ylcarbonyl] butyl-carbonyl] oxiran-2-carboxylate] sulfate (NCO-700) suppressed both activities of calcium activated neutral protease and cathepsin B isolated from cardiac muscle, showing 50% inhibition at 46 and 0.8 mumol/l, respectively."
3516158