IndraLab

Statements

Hydroxychloroquine activates carfilzomib. 8 / 8
| 8
reach
"HCQ has previously been shown to increase the efficacy of carfilzomib, but not bortezomib (34)."
38911853
reach
"We here show that HCQ potentiate the cytotoxic effect of carfilzomib on myeloma cells."
27683126
reach
"As expected, HCQ potentiated carfilzomib-induced myeloma cell death, but surprisingly, HCQ had little or no effect on bortezomib activity."
38067336
reach
"Bafilomycin A1 (the inhibitor of autophagy) and hydroxychloroquine (the drug interfering with autophagy and endocytosis) were both significantly increasing the efficiency of carfilzomib in killing can[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36170818
reach
"Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells."
27683126
reach
"In vitro studies have shown that HCQ potentiates carfilzomib (K) toxicity towards myeloma cells and could therefore be an attractive treatment option in myeloma (Baranowska, 2016)."
| PMC
reach
"To investigate whether the ability of HCQ to potentiate the effects of carfilzomib is not only confined to relatively rapidly proliferating cell lines, we also tested the effects of combining carfilzomib and HCQ-treatment on 5 isolates of CD138 + primary myeloma cells, as previously described [XREF_BIBR]."
27683126
reach
"HCQ potentiates the cytotoxic effect of carfilzomib on several multiple myeloma cell lines."
27683126