IndraLab

Statements

Hydroxide inhibits CTSL. 2 / 2
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"Although the molecular mechanism by which 1alpha,25 (OH) 2 D 3 inhibits CTSL activity is poorly understood, some studies have indicated that the effect might be mediated by cystatins, endogenous inhibitors of cathepsins."
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"In addition, our data in BOGA cells show that 1alpha,25 (OH) 2 D 3 inhibits CTSL mediated degradation of 53BP1, and most 1alpha,25 (OH) 2 D 3 actions require a functional nuclear VDR."
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