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Hydrogen chloride inhibits CTSB. 3 / 3
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"Assessment of the effect of protease inhibitors on the capacity of MCF-7 cells to incorporate [3 H] E 2 confirmed our enzyme immunological data : four lysosomal inhibitors (i.e. chloroquine, NH 4 Cl, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Firstly, D6 and DAPT reduced in vitro cathepsin B activity (Fig.  xref d) and lowered the levels of mature cathepsin B (Fig.  xref e, f) in SH-APPswe but not in SH-mock cells (Fig.  xref e), while NH 4 Cl strongly inhibited cathepsin B in both cell types (Fig.  xref d–f)."
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"To examine whether the release of CTSB from lysosomes was involved in morphine-induced NLRP3 inflammasome activation, we treated BV2 cells with 10 mM NH Cl to inhibit CTSB activity by moving lysosomal pH above its optimal activity [53]."
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