IndraLab

Statements

Hydroxychloroquine increases the amount of IL6. 5 / 6
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"This is in line with the observations in the current study, which shows that HCQ only mildly modulated RIG-I-mediated IFNα production in PBMCs, without affecting IL-6 release."
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"By contrast, HCQ did not affect hepatic insulin sensitivity and insulin clearance, but led to a significant reduction in circulating IL-6 levels along with a significant increase in adiponectin levels [93]."
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"In HT-29 colorectal cancer cells and H1299 lung cancer cells, we observed that choloroquine and hydroxychloroquine increase expression of ACE2, TMPRSS2 and IL-6."
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"HCQ significantly promoted the secretion of TNF-α and IL-6, but reduced IL-10 production by IL-4-cultured BMDM-M2 macrophages ( Fig. 6 E, F and 6G), further supporting the ability of HCQ to repolarize[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, in a human first-trimester trophoblast cell line (SVneo-transformed HTR8 cells), HCQ was able to partially reverse the aPL-mediated inhibition of cell migration despite the observation that HCQ treatment increased the secretion of promigratory IL-6 by trophoblasts [57]."
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