IndraLab

Statements

Amodiaquine inhibits histamine. 4 / 4
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"This effect was specific to the H2-receptor blocking activity of these drugs : equivalent degrees of receptor blockade by four different H2 antihistamines resulted in equipotent enhancement; H1-receptor antagonists did not alter histamine release; and aminoguanidine and amodiaquine, agents that inhibit histamine metabolism but do not block H2 receptors, did not enhance histamine release."
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"Augmentation of pentagastrin stimulated gastric secretion in the Heidenhain pouch dog by amodiaquine : inhibition of histamine methyltransferase in vivo?"
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"In this perspective, the HNMT inhibitor amodiaquine prioritized by SAveRUNNER/GSEA analysis might likely be used to restore a proper histamine balance and ameliorate MS conditions.While the HNMT expression data that we presented would not exclude histamine as a possible mediator implicated in the pathogenesis of MS, the frequencies of HNMT genotypes and allelic variants do not differ significantly between MS patients and controls, and are also unrelated with the age of onset, gender, course, and risk for the disease [61]."
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"L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl."
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