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Aldosterone inhibits ACE2. 17 / 17
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"In MPM obtained from p47 knockout mice, where NADPH oxidase is inactive, as well as in control MPMs treated with NADPH oxidase inhibitor, aldosterone did not increase ACE or decrease ACE2."
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"The later suggestion is less likely as both aldosterone and high salt diets have been found to downregulate ACE2 (Bernardi et al., 2012), unless the combination of DOCA‐salt and salt co‐treatment and reduced renal mass alters the RAS differently from any one of the treatments on their own."
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"The results of the present study showed that aldosterone down-regulates ACE2 via the NFkappaB pathway, and the decrease in ACE2 did not appear to have been caused by destruction of the brush-border membrane, because megalin staining, a marker of the brush-border membrane, was unchanged in the aldosterone group."
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"Aldosterone antagonists such as spironolactone and eplerenone may prevent ACE2 downregulation, restore the equilibrium of Ang I and Ang-(1-7), and reduce viral priming."
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"However , in MPMs treated with NADPH oxidase inhibitor , aldosterone could not increase ACE or decrease ACE2 suggesting these effects to be mediated in part by NADPH oxidase [ 43 ] ."
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"XREF_FIG revealed the presence of ACE2 on the brush-border membrane of the proximal convoluted tubules (PCT) in the control group and that ACE2 staining was markedly decreased by aldosterone."
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"High levels of aldosterone downregulates ACE2, decreasing the number of entry points for SARS-CoV2."
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"Aldosterone reduces ACE2 expression [ 15 ] , mineralocorticoid block with spironolactone increases expression [ 16 ] ."
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"The results also showed that ACE2 is down-regulated by aldosterone via NFkappaB activation, and the decrease in ACE2 expression was confirmed by real-time PCR and Western blotting."
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"Patients with PAH have clinical markers indicating activation of the sympathetic nervous system (i.e., elevated circulating catecholamine levels, muscle sympathetic nerve activity, heart rate variability, decreased MIBG uptake) and the renin-angiotensin-aldosterone system (i.e., increased renin activity, elevated levels of angiotensin I and aldosterone, decreased ACE2 activity and related peptides)."
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"Recent findings also report a positive effect of bariatric surgery on the renin–angiotensin–aldosterone system (reduction in plasma renin activity, plasma aldosterone and angiotensin-converting enzyme 2 activity) associated with a reduction in LVMI and improvement in E/e’ [24]."
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"High levels of aldosterone downregulates ACE2 , decreasing the number of entry points for SARS-CoV2 ( Murck , 2020 ) ."
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"In conclusion, the results of this study showed that aldosterone activates NFkappaB in the kidney and that ACE2 is down-regulated by aldosterone."
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"The virus downregulates ACE2, as a result of which, the renin angiotensin aldosterone system is dysregulated."
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"Further, higher aldosterone level downregulates ACE2 in the kidney expressing 11β-HSD2 in the lung, epithelial cells, and other entry points for COVID-19 [133,134]."
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"An increase of aldosterone will block the activities of the ACE2 and as a consequence attenuate the counter regulatory balance ."
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"Studies in human and animal models have reported that aldosterone reduces ACE2 activity, and mineralocorticoid receptor antagonists increase ACE2 activity."
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