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Aldosterone inhibits ACE2. 23 / 23
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"The results also showed that ACE2 is down-regulated by aldosterone via NFκB activation, and the decrease in ACE2 expression was confirmed by real-time PCR and Western blotting."
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"High levels of aldosterone downregulates ACE2, decreasing the number of entry points for SARS-CoV2."
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"However , in MPMs treated with NADPH oxidase inhibitor , aldosterone could not increase ACE or decrease ACE2 suggesting these effects to be mediated in part by NADPH oxidase [ 43 ] ."
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"The results of the immunofluorescence studies in Fig. 5 revealed the presence of ACE2 on the brush-border membrane of the proximal convoluted tubules (PCT) in the control group and that ACE2 staining was markedly decreased by aldosterone."
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"XREF_FIG revealed the presence of ACE2 on the brush-border membrane of the proximal convoluted tubules (PCT) in the control group and that ACE2 staining was markedly decreased by aldosterone."
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"The results also showed that ACE2 is down-regulated by aldosterone via NFkappaB activation, and the decrease in ACE2 expression was confirmed by real-time PCR and Western blotting."
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"Aldosterone reduces ACE2 expression [ 15 ] , mineralocorticoid block with spironolactone increases expression [ 16 ] ."
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"The results also showed that ACE2 is down-regulated by aldosterone via NFjB activation , and the decrease in ACE2 expression was confirmed by real-time PCR and Western blotting ."
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"Aldosterone antagonists such as spironolactone and eplerenone may prevent ACE2 downregulation, restore the equilibrium of Ang I and Ang-(1-7), and reduce viral priming."
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"High levels of aldosterone downregulates ACE2 , decreasing the number of entry points for SARS-CoV2 ( Murck , 2020 ) ."
33859954
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"The results of the present study showed that aldosterone down-regulates ACE2 via the NFkappaB pathway, and the decrease in ACE2 did not appear to have been caused by destruction of the brush-border membrane, because megalin staining, a marker of the brush-border membrane, was unchanged in the aldosterone group."
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"Patients with PAH have clinical markers indicating activation of the sympathetic nervous system (i.e., elevated circulating catecholamine levels, muscle sympathetic nerve activity, heart rate variability, decreased MIBG uptake) and the renin-angiotensin-aldosterone system (i.e., increased renin activity, elevated levels of angiotensin I and aldosterone, decreased ACE2 activity and related peptides)."
26056345
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"An increase of aldosterone will block the activities of the ACE2 and as a consequence attenuate the counter regulatory balance ."
| PMC
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"The results also showed that ACE2 is down-regulated by aldosterone via NFjB activation, and the decrease in ACE2 expression was confirmed by real-time PCR and Western blotting."
21072674
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"The reason for the differences in the results for glomerular staining was not investigated in the present study, but the differences in antibodies used in the previous and present studies may be responsible for the discrepancies.The results of the present study showed that aldosterone down-regulates ACE2 via the NFκB pathway, and the decrease in ACE2 did not appear to have been caused by destruction of the brush-border membrane, because megalin staining, a marker of the brush-border membrane, was unchanged in the aldosterone group."
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"The determination of the changes in the intrarenal reninangiotensin system should shed light on the exact role of ACE2 in aldosterone-induced kidney injury and should be performed in future studies.In conclusion, the results of this study showed that aldosterone activates NFjB in the kidney and that ACE2 is down-regulated by aldosterone."
21072674
eidos
"The results of the present study showed that aldosterone down-regulates ACE2 via the NFjB pathway , and the decrease in ACE2 did not appear to have been caused by destruction of the brush-border membrane , because megalin staining , a marker of the brush-border membrane , was unchanged in the aldosterone group ."
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"In MPM obtained from p47 knockout mice, where NADPH oxidase is inactive, as well as in control MPMs treated with NADPH oxidase inhibitor, aldosterone did not increase ACE or decrease ACE2."
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"The reason for the differences in the results for glomerular staining was not investigated in the present study, but the differences in antibodies used in the previous and present studies may be responsible for the discrepancies.The results of the present study showed that aldosterone down-regulates ACE2 via the NFjB pathway, and the decrease in ACE2 did not appear to have been caused by destruction of the brush-border membrane, because megalin staining, a marker of the brush-border membrane, was unchanged in the aldosterone group."
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"In conclusion, the results of this study showed that aldosterone activates NFkappaB in the kidney and that ACE2 is down-regulated by aldosterone."
21072674
eidos
"In conclusion , the results of this study showed that aldosterone activates NFjB in the kidney and that ACE2 is down-regulated by aldosterone ."
21072674
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"The determination of the changes in the intrarenal renin–angiotensin system should shed light on the exact role of ACE2 in aldosterone-induced kidney injury and should be performed in future studies.In conclusion, the results of this study showed that aldosterone activates NFκB in the kidney and that ACE2 is down-regulated by aldosterone."
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"Decreased ACE2 leads to an angiotensin II predominant state, increasing aldosterone, which augments angiotensinconverting enzyme expression, causing an enhanced breakdown of bradykinin, preventing the normal bradykinin-mediated increase in tPA.RAAS imbalance ultimately exacerbates microthrombi development."
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