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Hydroxychloroquine activates LC3B-II. 3 / 3
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"As expected, HCQ treatment alone or in concert with CPt or DTx consistently increased LC3B-II – the lower band consists of lipidated (conjugated to phosphatidylethanolamine) LC3B, referred to as LC3B-II, which is present in autophagosomes (Fig. 6A)."
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"Hydroxychloroquine (CQ), an autophagy inhibitor, enhanced the increase of LC3B-II but not Beclin1 in CSE or rHMGB1 treated MH-S cells, and inhibition of autophagy by CQ and 3-methyladenine (3-MA) abrogated the migration and p65 phosphorylation of CSE treated cells."
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"On the other hand, HCQ further enhanced the dieckol-induced accumulation of LC3B-II and p62, as well as the effect of dieckol on apoptosis regulatory proteins, caspase-3, PARP1, Bak, Bax, Bim, and Bcl-2 (Figure 4A,B)."
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