IndraLab

Statements

Hydroxychloroquine activates CASP3. 8 / 8
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reach
"A combined treatment of HCQ and anti-Fas mAb increased FLS apoptosis and caspase-3 activity synergistically, compared with either anti-Fas mAb or HCQ alone."
16734620
eidos
"According to Boya et al. ( 2003 ) , HCQ causes mitochondrial release of cytochrome c and activates caspase-3 ."
| PMC
reach
"Hydroxychloroquine can potentially increase apoptosis in FLS through its effects on the pro-apoptotic enzyme caspase-3 and enhances apoptosis mediated by CD95[29]."
36228471
reach
"The activation of caspase-3 by HCQ is very well reported in the literature."
| PMC
eidos
") The activation of caspase-3 by HCQ is very well reported in the literature ."
| PMC
reach
"CQ and HCQ can activate caspase-3 and modulate the Bcl-2 and Bax ratio inducing apoptosis in CLL, B-cell CLL and glioblastoma cells [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
29225688
ctd
No evidence text available
16734620
reach
"HCQ induced a significant decrease in cleaved caspase-3 and increase in Bcl-2 in pancreatic islet of Langerhans of diabetic rats as compared to the non-treated diabetic groups 23."
34104100