IndraLab

Statements

Hydroxychloroquine activates CASP3. 10 / 11
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"Hydroxychloroquine can potentially increase apoptosis in FLS through its effects on the pro-apoptotic enzyme caspase-3 and enhances apoptosis mediated by CD95[29]."
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"CQ and HCQ can activate caspase-3 and modulate the Bcl-2 and Bax ratio inducing apoptosis in CLL, B-cell CLL and glioblastoma cells [XREF_BIBR, XREF_BIBR, XREF_BIBR - XREF_BIBR]."
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"Further, Caspase-3 activity was apparently rescued by 3-MA or HCQ pre-treatment in Iso-incubated cells with UVB irradiation, and similar results were observed in the change of mitochondrial ROS ( Fig.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A combined treatment of HCQ and anti-Fas mAb increased FLS apoptosis and caspase-3 activity synergistically, compared with either anti-Fas mAb or HCQ alone."
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"HCQ induced a significant decrease in cleaved caspase-3 and increase in Bcl-2 in pancreatic islet of Langerhans of diabetic rats as compared to the non-treated diabetic groups 23."
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"The activation of caspase-3 by HCQ is very well reported in the literature."
| PMC
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"The expression level of Bcl-XL in BM-MDSCs was highly inhibited by HCQ, whereas the expression levels of Bax, caspase-3, and cleaved caspase-3 were significantly induced by HCQ treatment (Additional file 1: Fig. S4)."
35705919
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") The activation of caspase-3 by HCQ is very well reported in the literature ."
| PMC
eidos
"According to Boya et al. ( 2003 ) , HCQ causes mitochondrial release of cytochrome c and activates caspase-3 ."
| PMC
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"However, our results suggest that the combination of HCQ, losartan, and oxaliplatin significantly increases caspase-3 cleavage and leads to a strong reduction in tumor growth, supporting the potential of this drug combination to overcome oxaliplatin resistance in both models."
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