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1,2-bis(diphenylphosphino)ethane inhibits CTSB. 6 / 6
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"The cathepsin B activity of L. (L.) amazonensis amastigotes was inhibited by DPPE 1.1 as demonstrated spectrofluorometrically by use of a specific fluorogenic substrate."
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"Since we have shown here that DPPE 1.2 inhibits parasite cathepsin B, killing of L. (L.) amazonensis in infected mice treated with the drug may be associated to protective responses arising from lower expression of the active form of TGF-beta."
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"We showed that DPPE 1.1 inhibited the high cathepsin B activity expressed in L. (L.) amazonensis amastigotes."
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"The calculated IC50 values for DPPE 1.2 and CA074 were not significantly different (2.25±0.11 µM and 0.7±0.08 µM, respectively), strongly suggesting that DPPE 1.2 inhibits L. (L.) amazonensis cathepsin B."
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"DPPE 1.1 Inhibits the Cathepsin B Activity of L. (L.) amazonensis Amastigotes."
30018604
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"Since we have shown here that DPPE 1.2 inhibits parasite cathepsin B, killing of L. (L.) amazonensis in infected mice treated with the drug may be associated to protective responses arising from lower expression of the active form of TGF-β."
22616018