IndraLab

Statements

Hydroxychloroquine inhibits TMPRSS2. 2 / 2
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"Hoffman et al. reported that CQ and HCQ did not inhibit the entry of SARS-CoV-2 virus into lung cells in vitro , as CQ and HCQ did not target to pH-independent transmembrane serine protease TMPRSS2, w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Antivirals such as camostat mesylate (inhibitor of TMPRSS2), chloroquine and hydroxychloroquine (inhibitor of endocytosis), lopinavir and darunavir (inhibitor of 3-chymotrypsin-like protease) or ribavirin, remdesivir, favipiravir (inhibitor of RNA dependent RNA polymerase), or prednisolone should be restricted to controlled or randomized trials such as the worldwide WHO cosponsored Solidarity Trial (https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments)."
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