IndraLab

Statements

Hydroxychloroquine inhibits annexin. 3 / 3
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"Some experimental evidence suggests that hydroxychloroquine may decrease the risk of thrombosis by protecting the annexin A5 " anticoagulant shield " on vascular endothelial cells from being disrupted by aPL-beta2-glycoprotein I complexes XREF_BIBR, XREF_BIBR."
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"15 More recently, Rand et al. have demonstrated that HCQ reverses the binding of aPL-beta 2 GPI complexes to phospholipid bilayers and protects the annexin A5 anticoagulant shield from disruption by aPL."
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"Hydroxychloroquine (HCQ) has been shown to reverse aPL-mediated disruption of annexin A5 crystal structures that shield phospholipid, with inhibition of coagulation reactions and implications for thrombosis and pregnancy complication [48]."
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