IndraLab

Statements

Hydroxychloroquine activates (-)-epicatechin-3-O-gallate. 7 / 7
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"In 7-day ECG, excessive prolongation of QTc was observed in patients treated with hydroxychloroquine alone or in combination with azithromycin."
33512742
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"47 Frequent ECG monitoring in patients treated with chloroquine or hydroxychloroquine is also suggested."
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"At the time of the ECG assessment, 37 patients were treated with hydroxychloroquine with a daily dose of 6mg/kg, but four patients did not receive it because three of them were glucose-6-phosphate dehydrogenase deficient and one patient had a familial retinal disease."
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"The KardiaMobile-6L (AliveCor, Inc.) recently received FDA emergency clearance for QTc monitoring and was demonstrated as a feasible alternative to ECG QTc measurements in COVID-19 patients treated with hydroxychloroquine, lopinavir-ritonavir, and/or azithromycin [63], medications under investigation for treatment of COVID-19 at the time with known increased risk of QT prolongation particularly in combination [64, 65]."
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"Additionally, and because HCQ could prolong QTc, caution and ECG monitoring are required when using it, particularly in combination with other QTcprolonging medications [2, 7] ."
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"Interestingly, higher baseline QTc were observed in the population where HCQ+AZ has to be interrupted, highlighting the need for careful monitoring when initial QTc values are above 430 ms.To date, there is very few data evaluating the ECG modifications induced by the HCQ + AZ combination in the context of COVID-19 infection."
| PMC
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"Although chloroquine and hydroxychloroquine do prolong the ECG J to T-peak interval and are potentially ‘torsadogenic’, the extent to which the risk of TdP is increased is unclear."
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