IndraLab

Statements

Hydroxychloroquine decreases the amount of cholesterol. 11 / 11
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"HCQ also reduces the plasma levels of cholesterol, triglycerides and LDL and their clearance rate would be increased by the up-regulation of LDL receptors [XREF_BIBR]."
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"Wallace et al. [49] showed that in RA and SLE, treatment with HCQ lowered the levels of cholesterol, triglycerides and LDL, irrespective of concomitant steroid administration, diet, or weight."
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"Nevertheless, CQ or HCQ may lead to lower levels of cholesterol, as HCQ was recently found to lower total cholesterol in a large study of patients with systemic lupus erythematosus and rheumatoid arthritis, where CQ and HCQ are common treatment options (45)."
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"Hydroxychloroquine decreases LDL-C and total cholesterol levels [124] ."
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"In addition, many other clinical studies found that treatment with HCQ in RA reduces the levels of cholesterol, triglycerides and LDL irrespective of concomitant steroid administration [11,12] ."
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"Compared with the control group, the results also showed that HCQ challenge significantly decreased the levels of total cholesterol (CHO), high-density lipoprotein (HDL), and low-density lipoprotein ([MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Hydroxychloroquine reduces low-density lipoprotein cholesterol levels in systemic lupus erythematosus : a longitudinal evaluation of the lipid lowering effect."
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"COMMENTSOur results suggest that HCQ lowers cholesterol and LDL-C levels in women with RA and SLE."
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"Compared with the control group, the results also showed that HCQ challenge significantly decreased the levels of total cholesterol (CHO), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), but not the level of total triglyceride (TG)."
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"However, CQ disables acetyl-coenzyme A, required in initial events of cholesterogenesis in the endoplasmic reticulum, suggesting that HCQ lowers cholesterol levels by increasing the pH in the endoplasmic reticulum [37]."
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"In addition to its anti-inflammatory properties, HCQ reduces cholesterol and blood glucose levels and has antithrombotic effects."
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