IndraLab

Statements

Hydroxychloroquine activates PDLIM7. 7 / 7
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"In agreement with our result, other studies also have exploited LMP-inducing agents (i.e. PEI, hydroxychloroquine) in combination with the target antigen to enhance antigen cross-presentation and subs[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"CQ (chloroquine) and HCQ (hydroxychloroquine), V-Type H -ATPase, agents interfering with sphingolipid metabolism, and HSP70 antagonists are four typical inducers of LMP [120]."
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"Similarly, hydroxychloroquine treatment was reported to increase LMP induction and CB release, which was responsible for apoptotic cell death in pcDNA3.1, human Bcl2 vector transfected HeLa, and BJAB cells."
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"Now although HCQ has long been established as an autophagy inhibitor , work by the Boya team showed that HCQ induces LMP and MOMP , resulting in hallmark autophagic and apoptotic cell death [ 39,40 ] ."
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"Although HCQ and other chloroquine derivatives were originally proposed to deacidify the lysosome and promote lysosome membrane permeabilization (LMP), multiple studies by the Amaravadi lab identified palmitoyl-protein thioesterase 1 (PPT1) as the molecular target of chloroquine and its derivatives (4, 5)."
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"This data conflicts with data published by Boya et al. ( 2003 ) where they argue that HCQ induces LMP ."
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"This data conflicts with data published by XREF_BIBR where they argue that HCQ induces LMP."
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