IndraLab

Statements

Hydroxychloroquine decreases the amount of CD154. 10 / 10
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"HCQ inhibits CD154 expression through inhibition of sustained Ca 2+ storage release from the endoplasmic reticulum."
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"In the data already presented, we confirmed that HCQ blocked ionomycin induction of CD154 expression and intracellular Ca 2+ response."
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"These results indicate that HCQ suppresses CD154 expression by inhibiting nuclear translocation of NFATc2 in lupus CD4 + T cells."
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"Therefore, combined with our previous results, we were convinced that HCQ attenuated CD154 expression in SLE patients partially by inhibiting NFAT signaling."
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"Therefore the results revealed that HCQ treatment did not inhibit membranous CD154 expressed through the IL-15-mediated STAT5 signaling pathway."
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"In this study, we found that HCQ could attenuate membranous CD154 expression in activated CD4 + T cells from SLE patients via inhibition of the NFAT signaling pathway."
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"We reported that inhibition of CD154 expression by HCQ in T cells from SLE patients may be due to directly attenuating the CD154 transcription by inhibiting NFATc2 translocation and NFATc1 expression, not simply due to blocking T-cell activation."
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"Our study demonstrates that HCQ could abrogate CD154 expression through inhibiting the NFAT pathway in T cells; to our knowledge, this is a newly reported SLE therapeutic effect of HCQ, which may partially explain why HCQ has been well suited for SLE drug therapy."
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"Hydroxychloroquine inhibits CD154 expression in CD4 + T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling."
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"Results showed that HCQ inhibited CD154 expression in CD4 + T cells with 20% reduction at 5x standard concentration (= 3000ng/ml) and more than 50% reduction at 25x standard concentration treatment."
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