IndraLab

Statements

Amodiaquine inhibits glutathione. 4 / 4
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"In contrast to other antimalarial agents, amodiaquine (because it contains a 4-aminophenol function) depleted glutathione in activated neutrophils, by formation of an electrophilic quinoneimine metabolite."
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"Substitution of the 4 '-hydroxyl group in amodiaquine with a fluorine, by preventing oxidation to the quinone- imine, completely abolished the depletion of intracellular glu- tathione."
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"In the presence of PMA, there was enhanced depletion of glutathione by amodiaquine, which was concentration-de- pendent and reached a minimum of 46.7 +/- 7.1% of solvent control values (1.9 +/- 0.1 nm[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ginsburg H, Famin O, Zhang J, Krugliak M. Inhibition of glutathione dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action."
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