IndraLab

Statements

Hydroxychloroquine inhibits IFNA. 31 / 32
| 5 26
reach
"Although DCs have been implicated in the pathogenesis of several autoimmune diseases, a primary defect in DC function has not been reported to be crucial in initiating an autoimmune disorder.In SLE pa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25449681
reach
"Several studies have demonstrated that HCQ reduces the production of cytokines, including TNF-α, IL-6, IFN-α.20,21 It is possible that the inhibition of TNF-α, IL-6, and IFN-α expression alleviates the inflammation response resulting from mesangial cell activation."
36874354
reach
"In SLE and RA patients, HCQ affects TLR7 and TLR9 activation and decreases the percentage of DCs as well as their production of IFN-α (Sacre et al., 2012; Alves et al., 2017; Hjorton et al., 2018; Zeidi et al., 2019; Meng et al., 2022), IL-6 (Piconi et al., 2011; Hjorton et al., 2018; Meng et al., 2022) and TNF-α (Sacre et al., 2012; Hjorton et al., 2018; Han et al., 2020)."
38375029
eidos
"Preliminary report by Onodi et al. ( 55 ) suggested that HCQ might prevent the activation , differentiation and IFN-alpha production by pDC , thereby preventing an efficient response to SARS-CoV-2 ."
33692788
reach
"Chloroquine (CQ) and hydroxychloroquine (HCQ) reduce IL-1, IL-6, IFN-alpha and TNFalpha by inhibiting major histocompatibility complex (MHC II), antigen presentation and immune activation."
33278517
eidos
"Chloroquine and hydroxychloroquine Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
eidos
"QC was more effective than HCQ at inhibiting the toll receptor-mediated production of TNF-alpha and IL-6 in the peripheral blood mononuclear cells isolated from cutaneous lupus erythematosus patients , whereas QC and HCQ inhibited IFN-alpha equally ."
30227141
reach
"Studies have demonstrated that CQ and HCQ inhibited the production of IFN-alpha and IFN-gamma and/or TNF-alpha (XREF_TABLE) [XREF_BIBR]."
33062720
reach
"suggested that HCQ might prevent the activation, differentiation and IFN-alpha production by pDC, thereby preventing an efficient response to SARS-CoV-2."
33692788
reach
"Also, HCQ inhibited the production of IFN-alpha (XREF_TABLE) in pDCs in vitro, either after stimulation by DNA containing immune complexes or upon activation with TLR-9 agonists [XREF_BIBR]."
33062720
eidos
"Chloroquine and hydroxychloroquine Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
eidos
"[ 14 ] HCQ does not consistently inhibit tumor necrosis factor ( TNF-alpha ) , but blocks interleukin 1 ( IL-1 ) , IL-6 , and IFN-alpha production ."
32695719
reach
"This was not related to possible differences in ssRNA and pARG complex between experiments since different donors were tested on the same day using the same ssRNA preparation and we still observed variability in HCQ mediated IFNalpha inhibition (XREF_SUPPLEMENTARY)."
30846987
reach
"In support of this observation, administration of hydroxychloroquine -an inhibitor of IFNalpha production by PDCs through alterations of endodomal function- is beneficial in the management of musculoskeletal complaints in the setting of both lupus and SS [XREF_BIBR] [XREF_BIBR]."
26183766
reach
"Hydroxychloroquine also has immunomodulatory effects, and has been reported to decrease IL-1, IL-2, IL-6, IL-17, IL-22, IFN-alpha, and tumor necrosis factor [XREF_BIBR, XREF_BIBR]."
| PMC
reach
"Importantly, HCQ has been shown to inhibit the production of IFN-alpha in pDCs in vitro, either after induction by DNA containing immune complexes [XREF_BIBR] or upon stimulation with TLR-9 agonists [XREF_BIBR]."
22734582
reach
"LEF alone dose-dependently inhibited proliferation of T and B cells, production of cytokines CXCL13, IFN-alpha and IFN-gamma and production of IgG and IgM.3.2 Suboptimal concentrations of the HCQ and LEF combination additively inhibit T cell proliferation, B cell proliferation and CXCL13 production (in pSS patients) and inhibit IFN-alpha and immunoglobulinsNext, we investigated the effects of the combination of csDMARDs in this culture system."
31192747
reach
"We also detected the cytokine production in the supernatants of purified DCs stimulated with RA patient serum with or without HCQ, and we found that HCQ inhibited the secretion of IFN-alpha, but not TNF-alpha and IL-1beta (XREF_FIG D)."
33049581
reach
"Considering their pivotal immunomodulatory and anti-inflammatory potentials, CQ and HCQ are known to inhibit TLRs (TLR-3,7, 8 and 9); Interferons (IFN-alpha, IFN-gamma); T-cells (Th1, 2 and 17); TNF-alpha and interleukins (IL-1, 2, 6, 17, 22,) and act as a facilitator for IL-10."
33722600
reach
"Since at this concentration no inhibition of T cell proliferation, CXCL13, IFNgamma or IFNalpha production was observed HCQ seems to target B cells independent of these processes.We demonstrate that both LEF and HCQ inhibit T and B cell proliferation and production of CXCL13, IFN-alpha, IFN-gamma and immunoglobulins IgG and IgM, all of which are important contributors to pSS pathology, albeit with different potencies."
31192747
reach
"Importantly, hydroxychloroquine (HCQ) reduces IFNalpha production and preeclampsia in SLE women, XREF_BIBR, XREF_BIBR, XREF_BIBR improves endothelial function in an in vitro model of preeclampsia XREF_BIBR and in SLE mice, XREF_BIBR as well as prevents placental inflammation and fetal loss in mice [XREF_BIBR, XREF_BIBR]."
32680723
reach
"QC was more effective than HCQ at inhibiting the toll receptor mediated production of TNF-alpha and IL-6 in the peripheral blood mononuclear cells isolated from CLE patients, whereas both QC and HCQ equally inhibited IFN-alpha."
30227141
reach
"HCQ interferes with the TLR7 and TLR9 signaling pathways, reducing the production of IFNalpha, IL-6, and TNF-alpha [XREF_BIBR]."
29670462
reach
"In a culture system mimicking pSS pathology by TCR/TLR9 stimulation of PBMCs of pSS patients, a combination of LEF and HCQ complementarily inhibited T and B-cell proliferation, production of IFN-α, CX[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29526636
reach
"In vitro studies have shown that HCQ decreases the production of TNF-α, IL-6 and IFN-α by mitogen-stimulated peripheral blood lymphocytes [12]."
25348033
reach
"Probably, HCQ inhibits IFN-alpha production by limiting endosome maturation and the binding of TLRs to ICs containing self-DNA and RNA [XREF_BIBR]."
25229821
reach
"In vitro studies have shown that HCQ decreases the production of TNF-α, IL6 and IFN-α by mitogen-stimulated peripheral blood lymphocytes [ 37 ]."
29842927
reach
"An interpretation of this effect is that HCQ attenuates cellular production of IFN-alpha when mediated by TLR ligation but not the downstream effects resulting from subsequent stimulation by IFN-alpha and the elevations in IFN-alpha responsive genes tracking disease activity in SLE."
26683146
reach
"HCQ and CQ inhibit major histocompatability complex (MHC) class II expression; production of IL-1, IFNalpha and TNF and interfere with cyclic GMP-AMP synthase activity partly by accumulating in lysosomes and autophagosomes of phagocytic cells and changing local pH concentrations [XREF_BIBR]."
33542445
reach
"In addition, hydroxychloroquine (HCQ), a drug frequently used in the treatment of SLE, is involved in the downregulation of TLR signaling, causing a reduction of IFNalpha production by pDCs in SLE patients [XREF_BIBR]."
33535377
reach
"To examine this difference in more detail, we studied how potently MHV370 or HCQ suppressed immune-complex-induced IFN-α responses in a patient who was autoantibody positive for RNP/Sm plus dsDNA."
37196635