IndraLab

Statements

Hydroxychloroquine inhibits IFNA. 26 / 27
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"Chloroquine (CQ) and hydroxychloroquine (HCQ) reduce IL-1, IL-6, IFN-alpha and TNFalpha by inhibiting major histocompatibility complex (MHC II), antigen presentation and immune activation."
33278517
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"Preliminary report by Onodi et al. ( 55 ) suggested that HCQ might prevent the activation , differentiation and IFN-alpha production by pDC , thereby preventing an efficient response to SARS-CoV-2 ."
33692788
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"Chloroquine and hydroxychloroquine Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
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"Also, HCQ inhibited the production of IFN-alpha (XREF_TABLE) in pDCs in vitro, either after stimulation by DNA containing immune complexes or upon activation with TLR-9 agonists [XREF_BIBR]."
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"We also detected the cytokine production in the supernatants of purified DCs stimulated with RA patient serum with or without HCQ, and we found that HCQ inhibited the secretion of IFN-alpha, but not TNF-alpha and IL-1beta (XREF_FIG D)."
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"QC was more effective than HCQ at inhibiting the toll receptor mediated production of TNF-alpha and IL-6 in the peripheral blood mononuclear cells isolated from CLE patients, whereas both QC and HCQ equally inhibited IFN-alpha."
30227141
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"Chloroquine and hydroxychloroquine Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
eidos
"Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
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"HCQ interferes with the TLR7 and TLR9 signaling pathways, reducing the production of IFNalpha, IL-6, and TNF-alpha [XREF_BIBR]."
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"In support of this observation, administration of hydroxychloroquine -an inhibitor of IFNalpha production by PDCs through alterations of endodomal function- is beneficial in the management of musculoskeletal complaints in the setting of both lupus and SS [XREF_BIBR] [XREF_BIBR]."
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"Hydroxychloroquine also has immunomodulatory effects, and has been reported to decrease IL-1, IL-2, IL-6, IL-17, IL-22, IFN-alpha, and tumor necrosis factor [XREF_BIBR, XREF_BIBR]."
| PMC
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"QC was more effective than HCQ at inhibiting the toll receptor-mediated production of TNF-alpha and IL-6 in the peripheral blood mononuclear cells isolated from cutaneous lupus erythematosus patients , whereas QC and HCQ inhibited IFN-alpha equally ."
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"Importantly, hydroxychloroquine (HCQ) reduces IFNalpha production and preeclampsia in SLE women, XREF_BIBR, XREF_BIBR, XREF_BIBR improves endothelial function in an in vitro model of preeclampsia XREF_BIBR and in SLE mice, XREF_BIBR as well as prevents placental inflammation and fetal loss in mice [XREF_BIBR, XREF_BIBR]."
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"In vitro studies have shown that HCQ decreases the production of TNF-α, IL-6 and IFN-α by mitogen-stimulated peripheral blood lymphocytes [12]."
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"Importantly, HCQ has been shown to inhibit the production of IFN-alpha in pDCs in vitro, either after induction by DNA containing immune complexes [XREF_BIBR] or upon stimulation with TLR-9 agonists [XREF_BIBR]."
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"Considering their pivotal immunomodulatory and anti-inflammatory potentials, CQ and HCQ are known to inhibit TLRs (TLR-3,7, 8 and 9); Interferons (IFN-alpha, IFN-gamma); T-cells (Th1, 2 and 17); TNF-alpha and interleukins (IL-1, 2, 6, 17, 22,) and act as a facilitator for IL-10."
33722600
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"Chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) reduce IL-1 , IL-6 , IFN-alpha and TNFalpha by inhibiting major histocompatibility complex ( MHC II ) , antigen presentation and immune activation ."
33278517
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"Studies have demonstrated that CQ and HCQ inhibited the production of IFN-alpha and IFN-gamma and/or TNF-alpha (XREF_TABLE) [XREF_BIBR]."
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"Probably, HCQ inhibits IFN-alpha production by limiting endosome maturation and the binding of TLRs to ICs containing self-DNA and RNA [XREF_BIBR]."
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"This was not related to possible differences in ssRNA and pARG complex between experiments since different donors were tested on the same day using the same ssRNA preparation and we still observed variability in HCQ mediated IFNalpha inhibition (XREF_SUPPLEMENTARY)."
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"In addition, hydroxychloroquine (HCQ), a drug frequently used in the treatment of SLE, is involved in the downregulation of TLR signaling, causing a reduction of IFNalpha production by pDCs in SLE patients [XREF_BIBR]."
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"HCQ and CQ inhibit major histocompatability complex (MHC) class II expression; production of IL-1, IFNalpha and TNF and interfere with cyclic GMP-AMP synthase activity partly by accumulating in lysosomes and autophagosomes of phagocytic cells and changing local pH concentrations [XREF_BIBR]."
33542445
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"Preliminary report by Onodi et al. ( 55 ) suggested that HCQ might prevent the activation , differentiation and IFN-a production by pDC , thereby preventing an efficient response to SARS-CoV-2 ."
33692788
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"We also detected the cytokine production in the supernatants of purified DCs stimulated with RA patient serum with or without HCQ, and we found that HCQ inhibited the secretion of IFN-alpha, but not TNF-alpha and IL-1beta."
33049581
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"An interpretation of this effect is that HCQ attenuates cellular production of IFN-alpha when mediated by TLR ligation but not the downstream effects resulting from subsequent stimulation by IFN-alpha and the elevations in IFN-alpha responsive genes tracking disease activity in SLE."
26683146
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"suggested that HCQ might prevent the activation, differentiation and IFN-alpha production by pDC, thereby preventing an efficient response to SARS-CoV-2."
33692788