IndraLab

Statements


Hydroxychloroquine decreases the amount of IFNA. 6 / 6
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"Hydroxychloroquine suppressed endosomal TLR-induced IFNalpha and IL-6 release in vitro."

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"HCQ can inhibit the production of IL-1, IL-6, TNF-α, and IFN-γ in monocytes in vitro, as well as the secretion of TNF-α, IFN-α, IL-6, and other substances by plasmacytoid dendritic cells and natural killer cells (208, 210, 211)."

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"Moreover, both JP and HCQ dosages reduced TNF-α and IFN-α levels, with the effect of JP on reducing IFN-α being more significant ( Fig. 4 A)."

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"We found that IFN-α and λ levels were decreased by HCQ (Fig 4E) ."
| DOI

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"Addition of HCQ suppressed the expression of IFN-α, IFN-β, TNF-α, and IL-6 in both G/G and A/A pDCs (Supplemental Figure 10, A and B)."

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"SIGLEC1 and IFN-alpha expression were reduced by hydroxychloroquine and oral glucocorticoids."