IndraLab

Statements

Amodiaquine inhibits CTSB. 4 / 5
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"40 On the other hand, amodiaquine was an inhibitor of host-cell cathepsin B and was capable of increasing host cell viability by inhibiting Ebola virus replication."
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"CQ, monodesthyl chloroquine (mdCQ), amodiaquine (AQ), mdAQ, MF, and quinacrine inhibited cathepsin B in vitro."
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"In another study, it was proven that amodiaquine, an antimalarial drug, inhibited host Cathepsin B to protect host cells against infection with multiple toxins or viruses [ 192 ]."
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"Approved drugs already have well-established safety and pharmacokinetic (PK) profiles in humans and animals as well as existing manufacturing and distribution networks, which would potentially accelerate their approval.It has been previously discovered that a small molecule antimalarial amodiaquine (AQ) effectively inhibited LF-PA cytotoxicity by targeting host Ctsb."
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