IndraLab

Statements

Hydroxychloroquine inhibits PDLIM7. 14 / 14
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reach
"This was the first study to show that HCQ is able to block LMP."
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"Results : In vitro studies demonstrated that HCQ attenuated activation of the NLRP3 inflammasome and blocked LMP."
31556748
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"Results : In vitro studies demonstrated that HCQ attenuated activation of the NLRP3 inflammasome and blocked LMP ."
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"These data are consistent with HCQ being able to prevent LMP after cSiO2 exposure in vivo ."
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"Direct quantification of the ability of HCQ to block LMP in vitro was assessed through a method modified from Aits et al. which measures the release of beta-N-acetyl-glucosaminidase (NAG) into the cytosol after cell permeabilization by the detergent digitonin."
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"Our findings suggest that hydroxychloroquine blocks LMP and can significantly decrease cSiO 2 -induced toxicity in vitro."
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"The in vitro work from this study strongly supports the hypothesis that HCQ is able to block cSiO 2 -induced LMP."
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"These data are consistent with HCQ being able to prevent LMP after cSiO 2 exposure in vivo."
31556748
eidos
"Together , the in vitro data collected in these experiments are consistent with HCQ being able to reduce LMP after cSiO2 exposure ."
31556748
reach
"Together, the in vitro data collected in these experiments are consistent with HCQ being able to reduce LMP after cSiO 2 exposure."
31556748
reach
"Conclusions : Our findings suggest that hydroxychloroquine blocks LMP and can significantly decrease cSiO 2 -induced toxicity in vitro."
31556748
eidos
"This was the first study to show that HCQ is able to block LMP ."
31556748
reach
"In vitro studies demonstrated that HCQ attenuated activation of the NLRP3 inflammasome and blocked LMP."
31556748
eidos
"Conclusions : Our findings suggest that hydroxychloroquine blocks LMP and can significantly decrease cSiO2-induced toxicity in vitro ."
31556748