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Hydroxychloroquine inhibits LDH. 7 / 7
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"Although LDH activity was reduced by HCQ in vitro, when human erythrocytes were cultured in the presence of 20 mM HCQ, LDH activity was not significantly reduced for at least 5 h. Furthermore, HCQ res[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We have previously shown that HCQ inhibits LDH activity in vitro but has no effect on LDH activity in erythrocytes because the cytoplasmic tail of Band 3 (anion exchanger 1) strongly binds to the drug[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, we have shown that HCQ inhibits the activity of various LDH isozymes [9] ."
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"We have previously reported that HCQ inhibited LDH activity when assessed by monitoring of NADH oxidation (non-competitive inhibition) [9] ."
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"In the present study, we demonstrate that HCQ inhibits more strongly the LDH heterotetramer, H 2 M 2 , than the homotetramers, M 4 and H 4 ."
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"LDH activity is suppressed by HCQ."
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"These results indicated that HCQ binding to the cytoplasmic tail of Band 3 had a modest effect on its exchanger activity.We demonstrated that, as previously reported [4] and shown here for CQ, HCQ red[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27049308