IndraLab

Statements

Amodiaquine inhibits DNA-templated transcription. 3 / 3
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"A study published by our group showed that amodiaquine, an FDA-approved drug used against malaria, inhibited transcription of rDNA and enhanced proteasomal degradation of POLR1A followed by p53 stabilization [86]."
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"Herein, we report a novel activity of the FDA approved antimalarial drug amodiaquine which inhibits rRNA transcription, a rate limiting step for ribosome biogenesis, in a dose dependent manner."
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"An illustrative recent example is the discovery that the antimalarial drug amodiaquine inhibits rDNA transcription through a mechanism similar to a well-established inhibitor of RiBi, BMH-21 [ 80 ]."
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