IndraLab

Statements

Hydroxychloroquine activates MTX1. 7 / 7
| 7
reach
"The multicenter clinical trial TOWARD (TCZ in combination with traditional DMARD therapy) [XREF_BIBR], together with a majority of patients treated with MTX, included 387 patients treated with chloroquine and hydroxychloroquine, sulfasalazine, LEF (N = 97), parenteral gold salts, or azathioprine."
25830224
reach
"An explanation for this may be that HCQ increases the bioavailability of MTX and/or reduces the clearance of the drug [XREF_BIBR]."
26956382
reach
"HCQ is thought to support the pharmacokinetics of MTX, with higher peak and area under the curve concentrations of MTX, thereby enhancing the effect of MTX [18, 19]."
31431961
reach
"HCQ with MTX may increase MTX bioavailability and anti-inflammatory effects [56]."
38707172
reach
"Coadministration of hydroxychloroquine might increase the serum half-life of MTX, thus increasing therapeutic effect."
24612941
reach
"Research has shown that HCQ can increase the plasma concentration of MTX, thereby enhancing its bioavailability."
40342994
reach
"Although this study suggests that HCQ may increase systemic exposure to MTX by inhibiting ABCB1, the sensitivity of human ABCB1 to HCQ may be different from that of rats, and its clinical translational value should be carefully evaluated."
40342994