IndraLab

Statements

Hydroxychloroquine activates IL6. 6 / 6
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"In a randomised, double-blinded, placebo-controlled clinical trial of 40 asymptomatic patients with HIV-1, 800 mg/d hydroxychloroquine treatment for 8 weeks reduced the plasma concentration of HIV-1 RNA, preserved CD4+ T-cell counts and proliferative responses, and lowered serum IL-6 concentrations, compared with the placebo group.63 Although it takes 1–3 months for hydroxychloroquine and chloroquine to fully take effect in patients with rheumatic disease, the drugs' anti-viral effect is relatively rapid."
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"On the other hand, the immune-modulating effect of HCQ is represented in inhibition of signaling of the toll-like receptor and reducing the production of IL-1 and IL-6 [5]."
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"Hydroxychloroquine reversed the aPL-inhibition of trophoblast IL-6 secretion and partially limited aPL-inhibition of cell migration."
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"These pharmacological agents comprise non-specific immune modulators, such as corticosteroids, hydroxychloroquine, interferons, cardiovascular drugs, such as statins and renin–angiotensin–aldosterone system (RAAS) inhibitors, and specific immune modulators, such as Janus kinase (Jak) inhibitors, humanized anti-interleukin-6 (IL-6), anti-IL-1 receptor and anti-tumor necrosis factor alpha (TNF-α) monoclonal antibodies (34–41)."
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"This suggests that the preferential decrease of IL-6 production by HCQ may by mediated by its ability to decrease miR-21 expression."
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"Coincidently, chloroquine and hydroxychloroquine, as an established immuno-suppressor, can restrict hypercytokinaemia by suppressing IL-1β, IL-6, IL-12 [ 126 ]."
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