IndraLab

Statements

Cyclosporin A inhibits CTSL. 6 / 7
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"It was previously demonstrated that cyclosporine can prevent cathepsin-L–mediated degradation of synaptopodin."
22203053
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"Furthermore, CsA significantly inhibited the production of MMP-1, MMP-3, and cathepsin-L in HGFs [74,79]."
36359741
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"Nifedipine, cyclosporine and phenytoin selectively inhibited cathepsin-L activity (but not that of cathepsin-B) and mRNA expression in cultured gingival fibroblasts [92,93]."
36982523
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"43 Further work by Faul et al 25 showed a novel, nonimmunological role for cyclosporine in preventing cathepsin L–mediated degradation of synaptopodin."
22203053
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"An in vitro study showed that phenytoin and cyclosporine can inhibit the production of cathepsin L, but not B, by gingival fibroblasts [XREF_BIBR] and transgenic mice deficient for cathepsin L spontaneously develop GO [XREF_BIBR]."
21991476
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"Next, we monitored synaptopodin steady-state protein levels in the presence or absence of H89 and KN62 with or without CsA, E64 or E64D (a specific inhibitor of CatL)."
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