IndraLab

Statements



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"It is suggested that whereas chloroquine and amodiaquine inhibit the digestion of hemoglobin, mefloquine and possibly quinine inhibit the ingestion of host cell hemoglobin by interfering with the ingestion process."

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"This is evidenced by the ABS-active, liver stage-inactive 4-aminoquinolines chloroquine, amodiaquine and piperaquine that inhibit hemoglobin degradation and heme detoxification, and artemisinin derivatives whose activation inside parasites requires heme-iron that is a product of hemoglobin degradation 5."